Biological production puts a burden on the producing cells. In the conventional set-up this burden selects for the emergence of non-producing cells thereby preventing efficient bio-based production. Our technology prevents declining production at scale by 'addicting' the cells to high production. We call this technology Enduro Sense and we offer optimized production strain performance – in any organism and at every scale.
Enduro Sense is a simple genetic plugin that couples cell health with production – effectively making the cells addicted to the production of the desired product. This sustains fermentations over long time scales - and results in more high-producing cells.
Enduro Sense can be integrated seamlessly into existing strains or can be used right from the drawing board, providing a flexible way scaling up high-production strains.
Get more out of existing strains by enriching spontaneous high producers in the fermentation population – increasing yield, titer and rate
Enduro Sense is free of antibiotic resistance genes, making handling more compliant, easier and safer
Production of complex or cellular inhibit products is eased when strain instability is overcome
Getting started with Enduro Sense is easy. Integration of the Enduro Sense plugins can be done on site without transfer of strains. Contact us today to learn how to obtain a starter kit.
We offer flexible partner models that allow you to move fast forward and retain ownership.
We offer ultra-deep DNA sequencing of populations to profile escape routes of your strain designs
We understand the importance of conforming to desired data safety regulations and regulatory requirements.
WHAT CAN THIS TECHNOLOGY BE USED FOR?
Using Enduro Sense, cells maintain their productive state longer, which creates a more homogenous population and higher yield.
With our latest innovation (Enduro Sense 2.0), our proprietary platform technology is no longer product dependant, allowing us to unlock a new wave of bioproducts.
Technology of Enduro has been demonstrated in the commercial process of Aquaporin A/S, a Danish manufacturer of sustainable water filter solutions. Enduro re-engineered the production strain. The new production strain performed at least 45% better in lab-scale tests.
Error bars depict s.e.m. (n = 3).
In our constant R&D effort to deliver a more sustainable and efficient production process, we have been very satisfied working with Enduro Genetics.
Torsten Bak / Aquaporin A/S
Rugbjerg et al, 2018. Diverse Genetic Error Modes Constrain Biological Production, Nature Communications
Rugbjerg et al, 2018. Synthetic Product Addiction Extends the Productive Lifetime of Engineered Escherichia coli populations. PNAS
WO2017055360A1 A System For Improved Fermentation Titers
Relying on living organisms, bioproduction can be difficult to scale to large cultivation volumes while keeping titers high. By applying game-changing synthetic biology technology, we empower our partner companies to maximize performance of all cells cultivated from their production strains. By changing the desire of cells to produce, we increase competitiveness of current and future green bioproduction.
Based in Copenhagen, Denmark, Enduro is an independent service and tech provider committed to improving large-scale fermentations.
Contact us at email@example.com or +45 93 93 55 80.