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BIOPRODUCTION AT SCALE

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Enduro Sense - the future of bioproduction



Biological production puts a burden on the producing cells. In the conventional set-up this burden selects for the emergence of non-producing cells thereby preventing efficient bio-based production.
Our technology prevents declining production at scale by 'addicting' the cells to high production. We call this technology Enduro Sense and we offer optimized production strain performance – in any organism and at every scale.

Heterogeneity increases with rising cell generations.


What we offer

Enduro Sense

Enduro Sense is a simple genetic plugin that couples cell health with production – effectively making the cells addicted to the production of the desired product. This sustains fermentations over long time scales - and results in more high-producing cells.

Our Advantages

Seamless integration

Enduro Sense can be integrated seamlessly into existing strains or can be used right from the drawing board, providing a flexible way scaling up high-production strains.

Benefits

Our Advantages

Higher yield at scale

Get more out of existing strains by enriching spontaneous high producers in the fermentation population – increasing yield, titer and rate

Our Advantages

Antibiotic independence

Enduro Sense is free of antibiotic resistance genes, making handling more compliant, easier and safer

Our Advantages

Enable difficult processes

Production of complex or cellular inhibit products is eased when strain instability is overcome

Get started


Getting started with Enduro Sense is easy. Integration of the Enduro Sense plugins can be done on site without transfer of strains. Contact us today to learn how to obtain a starter kit.

Easy partnership model

We offer flexible partner models that allow you to move fast forward and retain ownership.

Fast and responsive

We offer ultra-deep DNA sequencing of populations to profile escape routes of your strain designs

Safety adapted to you

We understand the importance of conforming to desired data safety regulations and regulatory requirements.

WHAT CAN THIS TECHNOLOGY BE USED FOR?


Conventional Bioproduction

Heterogeneity increases with rising cell generations.

EnduroSense

Heterogeneity stays fixed with rising cell generations.

Using Enduro Sense, cells maintain their productive state longer, which creates a more homogenous population and higher yield.


Becoming product independent

With our latest innovation (Enduro Sense 2.0), our proprietary platform technology is no longer product dependant, allowing us to unlock a new wave of bioproducts.

Heterogeneity stays fixed with rising cell generations.

Testimonials

Industrial Aquaporin production strain was improved by Enduro

Technology of Enduro has been demonstrated in the commercial process of Aquaporin A/S, a Danish manufacturer of sustainable water filter solutions. Enduro re-engineered the production strain. The new production strain performed at least 45% better in lab-scale tests.

Error bars depict s.e.m. (n = 3).

In our constant R&D effort to deliver a more sustainable and efficient production process, we have been very satisfied working with Enduro Genetics.

Torsten Bak / Aquaporin A/S

Publications

Articles


nature.com

Rugbjerg et al, 2018. Diverse Genetic Error Modes Constrain Biological Production, Nature Communications


pnas.org

Rugbjerg et al, 2018. Synthetic Product Addiction Extends the Productive Lifetime of Engineered Escherichia coli populations. PNAS

Icon Publications

Patents


patents.google.com

WO2017055360A1 A System For Improved Fermentation Titers

Open positions

Currently, we have no open positions.
We always invite unsolicited applications from molecular biology and fermentation scientists to jobs@endurogenetics.com.
If you are interested in an internship or a student project, contact us with an email subject containing "intern" or "student project".

News

Enduro Genetics raises 470,000 EUR preseed

2020/12/02


The Danish biotech company Enduro Genetics raises a 470,000 EUR pre-seed from the Nordic biotech incubator, the BioInnovation Institute in Copenhagen.


Enduro Genetics wins a project with the US Agile BioFoundry

2020/07/20


Enduro Genetics' project proposal is selected to help accelerate biomanufacturing working with three US national labs.


Danish Biotech Turns Bacteria into Fermentation Workaholics

2019/01/21


Enduro Genetics announces results working with Danish biotech Aquaporin A/S.


Enduro

Vision

Relying on living organisms, bioproduction can be difficult to scale to large cultivation volumes while keeping titers high. By applying game-changing synthetic biology technology, we empower our partner companies to maximize performance of all cells cultivated from their production strains. By changing the desire of cells to produce, we increase competitiveness of current and future green bioproduction.

Mission

Based in Copenhagen, Denmark, Enduro is an independent service and tech provider committed to improving large-scale fermentations.

Learn more

Contact us at info@endurogenetics.com or +45 93 93 55 80.